S. John Calise

College of Medicine

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I am a cell biologist who studies how and why the enzyme inosine monophosphate dehydrogenase (IMPDH) forms large polymer structures in human cells, a process that is still not well understood. IMPDH is important for many cellular processes, such as DNA and RNA synthesis, proliferation, and G-protein signaling, and is thus a potential target for immunosuppressive, anticancer, and antiviral drugs. Our long-term goal is to exploit what we learn about IMPDH polymer formation in normal cell biology to improve existing therapies or design novel treatments targeting IMPDH for various diseases.